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Best CBD Oil For Anxiety and Depression 2021

CBD Oils are made from compounds found in Cannabis sativa, aka marijuana plant. As there was a heavy research put on this developing and proving its medical purposes, it can’t be denied that people abuse it since it’s highly addictive. It has been proven to manifest reduced anxiety and depression, relieve pain, good for the heart, and other major benefits.


  • Proven and Tested to Reduce Anxiety
  • relieves pain and fatigues
  • Great Benefits for skin health
  • Improves heart and circulatory system
  • high-quality THC Concentration
  • 90-day money back guarantee

After spending more than 40 hours reading the latest research papers and more than a month testing the most popular CBD oils on the market, we believe that the CBDPure is the best CBD oil for anxiety.

Unlike other products, this oil goes through rigorous testing and it’s FDA approved, so you can be certain you’re always getting the right quantity of the active substance in your system.

Moreover, the CBDPure is produced using organically grown hemp from Denmark, so the oil is not only 100% legal, but also very effective.

Now that we’re familiar with the anxiolytic effects of CBD oil, let’s take a look at the best products currently available on the market.

Top Products According to Experts



Ketosis Advanced



Keto Tone

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Best CBD Oil For Anxiety Reviews 2021 (UPDATED) 

1. CBDPure Hemp Oil

  • Per Serving Contains 20mg of Cannabidiol
  • 90-Day Money Back Guarantee

CBDPure incorporates everything you should want from high-quality CBD oil. The manufacturing company is a realiable source with a good reputation and the brand seems to be concentrating on providing the best CBD oil on the market.

One of the great things about CBDPure is that they release their products only after putting them through rigorous testing and after they get the FDA’s approval.

Not only does this mean the product has a high quality, but it also means you will get the same amount of cannabinoids in your system for every serving.

For best results, you simply have to place a decent amount of drops (0.5 ML - 1 ML) under your tongue and wait for it to be absorbed before swallowing it.

Moreover, the hemp used to extract the CBD is organically grown in legal fields in Denmark, which means the product is legal all over the US.

CBDPure is extracted using the CO2 method, and then it’s also cold pressed. Every drops provides a full spectrum of cannabinoids. 


  • 300 mg - contains 10 mg of cannabidiol per serving
  • 600 mg - contains 20 mg of cannabidiol per serving
  • 1000 mg - contains 33 mg of cannabidiol per serving


  • Each bottle contains less than 0.3% THC by weight
  • Natural and Organic Hemp Oil as well as the flavor
  • Backed by a 90-day Money Back Guarantee

Did you know...


Since the signing of 2018 Farm Bill, the prohibition of hemp oil across the United States has been lifted and was legalized as long as it don't go over 0.3% THC level.

Given its purity and effectiveness, we believe that the CBDPure is the best pick for most people.

2. Plus CBD Oil

plus cbd oil
  • Legally Recognized and Approved by FDA
  • Estimated Servings: 15 Drops per Bottle

Honestly, the Plus CBD oil is a strong runner-up. Plus CBD is also a reputable company, and they pay attention to every step of the manufacturing process, from seed to the finite products.

The hemp they use for the production does not contain traceable amounts of psychoactive compounds, making it suitable for medicinal use.​

Made from top-notch laboratories and they use an environmentally-friendly CO2 for extraction process. In double checking their products’ non-toxic extraction and it's quality, the manufacturer constantly tests them with the help of third-party testers for optimum condition. 

The great thing about all this testing and regulating is that it provides you the certitude that every serving contains the same amount of cannabinoids.

Plus CBD oils are approved by the FDA which means it is safe to take and is legally recognized.

The 100 mg oil delivers 1 mg of CBD per serving, the 250 mg one delivers 3 mg, the 500 mg provides 3 mg, and the 750 mg oil provides 5 mg of CBD.


  • Total Plant Complex
  • Raw Oil Drops
  • Oil Gold Drops


  • Has unique flavors like Peppermint, Goji Blueberry, Unsweetened, and Natural
  • High-Concentration of CBD
  • It can be added to shakes and smoothies which are great for people with active lifestyles.

Did you know...


CBD Oils are medically tested and FDA approved to contain less than 0.3% THC which doesn't get you high and at the same time giving you all the benefits of full-spectrum CBD without the intoxicating side effects.

The estimated serving is 15 drops and you should put them under your tongue for ideal results.

3. Green Roads CBD Oil

green roads cbd
  • American Farm Hemp and Independent Lab Tested
  • Active Ingredients: Hemp Derived Full Spectrum Cannabinoid Extract

Green Roads CBD is another great product. Green Roads World uses only non-GMO hemp plants cultivated without pesticides for their products. The company uses the CO2 extraction method to get the most of the cannabinoids in the plant, which means the final products will have a high purity. Their products go through an independent third party lab testing to double check the product’s quality. However, the Green Roads CBD is NOT approved by the FDA.

This product has been FDA and customer approved with a lot of positive feedback which they claim. Green Roads sold their oils to more than a million customers and they still have a good reputation. 

This is a clear indicator that their products have a high-quality.

The good thing about Green Roads World is that they offer some of the highest concentrations of cannabinoids.  

Using a syringe might seem like a good idea for those who choose a low-concentration product, the results can often be messy so we recommend using the dropper instead.


  • 15 ML (350 mg) - CBD/Serving of 23 mg / ML
  • 15 ML (550 mg) - CBD/Serving of 37 mg / ML 
  • 30 ML (1000 mg) - CBD/Serving of 33 mg / ML 
  • 30 ML (1500 mg) - CBD/Serving of 50 mg / ML
  • 60 ML (3500 mg) - CBD/Serving of 58 mg / ML


  • Flexible serving of CBD consistency
  • Non-GMO
  • Company also sells gummy to give people a different CBD experience. 

Did you know...


CBD Oils are better stored in a cool area which is not directly hit by the sunlight and has low humidity. The reason for this is that it will help in preserving the benefits and properties of the extracts. You could even extend its shelf life to a year.

Their products come with both a dropper and a syringe for a quicker administration. 

4. Purekana CBD Oil

  • Lab Tested / Made In the USA
  • Ingredients: Hemp oil Extract, MCT oil, Natural Flavors, Terpenes

Purekana CBD oil is a great option for those who are looking for a reliable source of full spectrum CBD. The good thing about Purekana is that their hemp products are legal in all the states as nutritional additives.

The company uses non-GMO hemp plants grown without pesticides, herbicides, or chemical fertilizers as their raw material.

The extraction process uses the CO2 method, and it’s environmentally-friendly. Thanks to the high-quality extraction process, the CBD oils contain a full spectrum of cannabinoids.

All Purekana oils go through a third party testing, but none of the products is FDA approved. 

The industrial hemp used for production contains less than 0.2% THC, so it’s suitable for medicinal use. 


  • 300 mg of high concentrated extract
  • 600 mg of high concentrated extract
  • 1000 mg of high concentrated extract
  • 2500 mg of high concentrated extract
  • 5000 mg of high concentrated extract


  • Purekana comes in flavors like natural, mint, and vanilla.
  • No pesticide, solvents, or other chemicals.
  • 30-Day Satisfaction Guaranteed

Did you know...


CBD Oils can have a great positive impact on health in general. Both in physical and mental, it can really be beneficial. It could greatly reduce your stress and anxieties as well as give you a good sleep.

However, even though this amount of THC is barely traceable, you should know that some drug tests are more sensitive than others, so the THC might come up during a drug screening.

What Is CBD Oil?


Cannabidiol (CBD) is one of the more than 100 chemical compounds called cannabinoids in the cannabis plant. And while researchers are still studying and discovering how each of these compounds could help humanity, the effects of cannabidiol and tetrahydrocannabinol (THC) are now well-known.

THC is the psychoactive cannabinoid in the marijuana plant, and it’s the one that gives you a “high”. Unlike THC, CBD does not produce mind-altering effects. But even though CBD doesn’t change the user’s state of mind, it seems to produce important changes in the human body.

How Is it Extracted?

Most of the CBD used for medicinal purposes comes from hemp. Both hemp and marijuana come from the Cannabis sativa plant, but they come from different strains of the plant. Over the years, farmers have bred the cannabis plant to suit their needs. Some plant strains contain high levels of CBD and barely any traceable THC, while others contain a lot of THC. High-CBD strains are commonly called industrial hemp, and they are the best strains for medicinal purposes.

One of the reasons people prefer these strains over the ones that contain THC is that they’re easier to process. If the strain would contain THC, the extraction process would first need to separate the CBD from the other cannabinoids, which would complicate the entire process and increase its price.

To avoid getting too technical, we’re only going to describe the extraction process for the industrial hemp.

1. Extraction Using Liquid Solvents

This is the simplest and cheapest extraction process, which makes it very popular among manufacturers. In this method, the plant material is introduced in a container. Liquid solvent - usually ethanol, butane, hexane, or isopropyl alcohol – is poured over the plant matter, stripping it of the cannabinoids which are transferred to the liquid. When the liquid evaporates, the chemicals are concentrated in the form of oil.

While this method is very popular thanks to its simplicity and low costs, it does have its downsides. The worst thing about it is that you can find solvent traces in the CBD oil, lowering its purity. Moreover, some solvents are so strong they remove some of the plant’s chlorophyll in the process, making the oil taste bitter.

2. Extraction Using Oils

This is also a simple extraction method, but since you have to use oil – especially olive oil – as a solvent, this method is more expensive than the previous one. In addition, since olive oil is highly perishable, this method is not suitable for large-scale commercial uses. However, this is a popular extraction method among individual enthusiasts and small local producers.

For this extraction method to work, you must first heat the plant material to a specific temperature to activate its chemical compounds. Then, the olive oil is added and the mixture is heated at 100 degrees Celsius for about two hours to extract the cannabinoids. Because the olive oil won’t evaporate after the extraction, the users must consume a larger quantity of CBD oil to get the same benefits as they would from concentrated oils.

3. Extraction Using Carbon Dioxide (CO2)

Depending on its pressure and temperature, CO2 can present itself as a gas, liquid, or solid. Since the molecule is affected by the environment’s pressure and temperature, this extraction method is done using special equipment. Therefore, this is the most expensive and technically complicated extraction process.

During the first step of the extraction process, solid CO2 is poured over the plant material. Then, the temperature and pressure inside the equipment changes and the CO2 starts changing into a liquid. At this point, the extraction process is similar with the one using solvents, and the plant’s chemicals and flavors are transferred to the liquid. Then, the pressure and temperature change again and the CO2 becomes a gas and it rises while the CBD oil remains at the bottom of the equipment, ready to be collected.

Even though it’s expensive and complicated, this extraction process also has several benefits. This is the quickest extraction method, and it also offers the purest finished product. The pressure and temperature differences can also separate the CBD from the THC if the hemp strain contains any.

Benefits of CBD Oil for Anxiety and Depression

Now that we have a clear understanding of what the endocannabinoid system is and how it works in our bodies, let’s see how the cannabinoids in the CBD oil can activate for our benefit.

Can Help With Pain Relief

CBD oil can produce pain relief. The cannabinoids in the oil are so similar to the ones our body produces that they interact with the receptors in the brain. This leads to a sequence of events that reduces inflammation and alleviates pain.

Some studies have found that CBD oil use can reduce the inflammation significantly without producing any side effects.

Fights Cancer

Unfortunately, CBD oil is not the cure for cancer. However, CBD can help limit cancer’s spread. Moreover, researchers found that the chemical compounds in CBD oil can suppress the growth of new cancer cells, helping the body fight the disease.

Here’s the deal, even though CBD cannot be called a cure for cancer, it’s so effective at fighting it that scientists are now looking into using it as an aid in standard cancer treatments.

Acne Treatment

The inflammation of the sebaceous glands is one of the things that cause acne. When the sebaceous glands are overworked, they become inflamed. Once the glands become inflamed, they produce more sebum than they should. Thanks to its anti-inflammatory effects, the CBD prevents the glands from becoming inflamed in the first place, reducing the risk of developing acne.

May Help You to Quit Smoking And Less Withdrawal

Quitting smoking is difficult. Your body craves the nicotine, and every minute you spend without smoking increases the stress you’re facing. Thanks to their regulating effect on stress response, cannabinoids can help smokers deal with novelty situations easier.

In addition, it seems that CBD oil might also have a positive effect on those who go through substance addiction withdrawal. CBD reduces some of the symptoms that are usually associated with withdrawal like pain, anxiety, insomnia, which makes the process more bearable.

Helps With Neurological Symptoms And Conditions

The FDA found that the use of CBD oil is effective for treating epilepsy, and approved the oil as a therapy method for neurological conditions that manifest as epileptic seizures. But here’s the kicker, CBD oil is now recommended for serious conditions such as Lennox-Gastaut syndrome and Dravet syndrome. Both conditions are difficult to control with other medications, but they can be managed with CBD oil.

Recent studies suggest that CBD oil could also treat some of the complications usually associated with epilepsy, such as neuronal injury or degeneration.

Apart from epilepsy, CBD oil could also be beneficial for those who suffer from schizophrenia. A meta-study that spanned for more than 30 years suggests that the chemical compounds found in CBD could produce results similar to those of antipsychotic drugs used to treat this condition.

Preliminary studies suggest that CBD can be beneficial in the early stages of Alzheimer’s. Those who use the oil might experience a slower progression of the disease, and they might recognize the faces of friends or family for a longer time.

Reduces The Risk Of Type 1 Diabetes

Type 1 diabetes is the result of an autoimmune attack. The immune system attacks and destroys the insulin-secreting cells in the pancreas, and as a result, those affected require insulin therapy.

Studies published recently show that CBD might ease the inflammation in the pancreas, which would protect the cells against the destructive process. This effect could delay or even prevent the development of type 1 diabetes.

How Does CBD Oil Works?

To find out how CBD oil works, we must first delve into the human physiology. But don’t worry, we’re not going to recite something we’ve read in a physiology manual. We’ll keep it short and factual.

The Endocannabinoid System

You probably already know that the human body has a central nervous system – AKA the brain and the spinal cord – and a peripheral nervous system – AKA the nerves contained outside the first two organs we just mentioned.

Now, you’re definitely familiar with neurotransmitters. They’re the substances that carry the nerve signals within the brain and spinal cord and from them all over the body. But here’s the thing, there are more types of neurotransmitters.

Each transmitter system relies on specific substances to work. For example, the adrenergic receptors work in the presence of epinephrine (adrenaline), but they won’t work in the presence of serotonin and histamine, even though these are neurotransmitter-activating substances as well.

As you could probably deduce by now, our bodies produce their own cannabinoids. These cannabinoids activate two types of receptors. The first type of endocannabinoid receptors are called CB1, and it’s mainly found in the brain. The second type of endocannabinoid receptors are called CB2, and it’s found both in the brain and in the peripheral nervous system.

The CB1 and CB2 receptors can only be activated in the presence of cannabinoids. Our body produces two types of cannabinoids called N-arachidonoylethanolamide (AEA) and 2-arachidonoylglycerol (2-AG).

The Role Of The Endocannabinoid System

Now, let’s take a look at the role of the endocannabinoid system in the body. Why is it important to stimulate it using CBD oil?

  • Memory – In a study conducted on rats, researchers discovered that the endocannabinoid system was closely linked to the formation and extinction of long-term memories.
  • Appetite – The endocannabinoid system is involved in our food-seeking behavior. It seems that cannabinoids decrease the amount of leptin in our blood. Leptin is a hormone that regulates our energy balance and has the potential to inhibit hunger.
  • Neurogenesis – The release of endocannabinoids seems to facilitate the birth of new neurons in the hippocampus
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    Stress Response – While our stress response is primarily controlled by the glucocorticoids, 2-AG can prevent the excessive production of glucocorticoids in a stressful situation.
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    Immune System – Endocannabinoids can regulate our immune response, and keep our immunoglobulin M at healthy levels.
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    Pain Response – Our bodies produce and distribute endocannabinoids at a faster rate when we’re in pain.
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    Metabolism – The endocannabinoid system seems to modulate the function of the endocrine pancreas. This may affect the body’s insulin sensitivity.
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    Exploration And Social Behavior – Endocannabinoids can mediate aggression and inhibit excessive arousal, helping regulate the body’s stress levels in new situations.
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    Sleep – An increased level of endocannabinoids in the central nervous system can promote sleep. It seems like the cannabinoids produced by our bodies follow a circadian rhythm.
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    Physical Exercise – Exercise increases the amount of endocannabinoids in the bloodstream.
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    Thermoregulation – Endocannabinoids seem to produce a sequence of processes that lead to vasodilatation, helping the body cool down faster.

How To Choose the Right One?

There are several things you should keep in mind when buying CBD oil for anxiety. We made this quick summary to help you make good decisions.

Raw Material

Cannabis plants are easily affected by their environment. Using pesticides, herbicides, or other chemicals will diminish the plant’s value. Moreover, plants that contain high doses of THC are not suitable for medicinal use.

Extraction Method

The extraction method is directly correlated with the product’s purity. And pure products are more effective. You should look for oils that have been extracted using the CO2 method.


All the companies that sell CBD claim their products have the best quality, but you should make certain you make the right choice. High-quality products are FDA-approved because they actually contain the amount of cannabinoids they claim to do.

CBD Oil Dosage for Anxiety: How To Use it Right?

The easiest way to use CBD oil for anxiety is to pour some in your mouth and to keep it under your tongue for at least a minute before swallowing it. You could also vape it or use it in food, but that won’t produce ideal results.

The Right Dosage

CBD oils have different potencies. However, the golden rule is to start with a small dose and increase it over time, no matter the potency. You should start with a dose of 25 – 50 mg of CBD per day and increase it until the condition improves.

You should increase the dosage gradually, once every 4 – 5 days, not all of the sudden. Keep in mind that your body needs some time to adjust to the oil’s effects.

What Do People Say About CBD Oil For Anxiety

When it comes to using CBD oil for anxiety, reviews can vary from extremely positive to very negative. As you can imagine, given the abundance of products now available on the market, CBD oil has some mixed reviews when it comes to treating any condition, not just anxiety. The high-quality products like the ones we presented have good reviews, but some of the others don’t.

Now, while we agree that some manufacturers do not produce effective oils, we believe that some customers are also to blame. Some people expect to see an instant change when they use CBD oil, but that’s not how it works. The cannabinoids need some time to produce any noticeable changes in your body. So, unless the customer used the oil consistently for 5 – 6 days at least, they wouldn’t be able to notice any changes.

And the thing is, the results differ for every person. Some people might notice a change in 2 days, some in 2 weeks. Just because your results are not the same to those of other people, it doesn’t mean they’re bad.

Why You Should Use it For Anxiety

If you’re looking for a natural alternative treatment for anxiety, you should definitely give CBD oil a try. Even though the scientific world is just starting to suggest and use CBD as a treatment option, the preliminary results look promising. Unlike the medicine that’s usually prescribed for anxiety, CBD oil does not cause significant side effects.

We’re certain that the future will reveal that CBD is more useful than we currently know, and it’s definitely one of the substances we’re expecting to learn more about. Until then, we will surely recommend it to anyone who suffers from anxiety and depression.



Scientists have been studying the effects of CBD oil for anxiety for quite some time now, and thanks to the CBD’s recent legalization, the research is going better than ever and the results are in.

Here’s the thing, depression and anxiety disorders are the most common mental disorders. They are highly prevalent in the world’s current population, and they have a strong impact on the sufferer’s feelings and moods. These disorders have variable severities and can last anywhere from months to years.

It’s estimated that over 300 million people suffer from a form of depression worldwide, and more than 40 million adults in the US alone. Even though anxiety disorders are highly treatable, only 43.2% of those who suffer from anxiety receive proper treatment in the US.

Both anxiety and depression are treated with prescribed pharmaceuticals, but most of these drugs can cause severe side effects such as drowsiness, headaches, insomnia, or sexual dysfunction. And it gets worse. Some of the drugs can be addictive, and they can eventually lead to substance abuse. This is why a lot of people are now looking for natural ways to treat these conditions.

Fortunately, CBD may help you manage anxiety and depression. Scientists believe that the cannabinoids in the CBD oil may change the way your brain reacts in the presence of serotonin, a neurotransmitter that’s often called “the happiness molecule”.

Like every other neurotransmitter, serotonin activates specific receptors in the brain. But the thing is, CBD seems to be able to activate some of serotonin’s receptors, which makes it valuable for those who suffer from anxiety and depression.

A study that compared the speech performances of those who consumed CBD with the performances of those who took a placebo found that the CBD group showed significantly less anxiety and discomfort.

And it gets better. CBD has shown promising results in treating insomnia and anxiety attacks in children who suffered from post-traumatic stress disorder (PTSD).

Since CBD constantly activates some of the serotonin receptors, it has antidepressant-like effects. Some studies show that the effect is so strong it’s similar to that of certain prescribed antidepressants.